Expert Insight View All

Foresight: The future directions of COVID-19 vaccination with bivalent BNT162b2 vaccine

From March 1, 2023, all the Coronavirus disease 2019 (COVID-19) restriction measures have been lifted in Hong Kong including the mask mandate, getting the society back to normal.1 However, there is a rebound of local COVID-19 cases caused by predominantly XBB, an Omicron sub-variant, and its descend

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Professor Stephen J. Thomas, MD

Professor of Medicine, Microbiology & Immunology
Frank E. Young, MD '56 and Leanne Young Endowed Chair of Microbiology and Immunology,
Director,
Institute for Global Health and Translational Science,

SUNY Upstate Medical University

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Research Spotlight View All

Navigating anticoagulation strategies for preventing recurrent events in NVAF patients with ischemic stroke despite DOAC

The increasing incidence of ischemic stroke in patients receiving direct oral anticoagulants (DOACs) highlights the heightened risk of subsequent ischemic events.1 Yet, the effectiveness and safety of antithrombotic regimens following this condition remain uncertain.1 In this investigation, patient outcomes were compared between those receiving DOACs with or without an alternative antithrombotic regimen, and the risk factors for recurrent ischemic stroke while on anticoagulation were identified.1 The 6-year study period, spanning January 1, 2015 to December 31, 2020, included 45,946 non-valvular atrial fibrillation (NVAF) patients administered DOACs for stroke prevention.1 Among them, 2,908 patients experienced an ischemic stroke despite the DOAC treatment, and 2,337 NVAF patients were included in the final analysis.1 The findings demonstrated that switching to warfarin (aHR=1.96; 95% CI: 1.27-3.02; p=0.002) or another DOAC(aHR=1.62; 95% CI: 1.25-2.11; p<0.001) was associated with an elevated risk of recurrent ischemic stroke compared with maintaining the sameDOAC therapy.1 Furthermore, the addition of an antiplatelet agent did not exhibit a reduced risk of recurrent ischemic stroke.1 The risk factors of recurrent ischemic stroke include diabetes mellitus (DM), concurrent cytochrome P450/P-glycoprotein (CYP/P-gp) modulators, and large artery atherosclerotic disease (LAD).1

30 Jun 2023
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Professor Leung Wai-Hong Thomas

Head of Division of Neurology
(Academic Affairs),
Lee Quo Wei Professor of Neurology
Assistant Dean (Education),
Faculty of Medicine,
The Chinese University of Hong Kong

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Dr. Ip, Yiu-Ming Bonaventure

Assistant Professor,
Department of Medicine and Therapeutics,
The Chinese University of Hong Kong

Ip YMB, et al. Association of Alternative Anticoagulation Strategies and Outcomes in Patients With Ischemic Stroke While Taking a Direct Oral Anticoagulant. Neurology. 2023.

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Transforming MCL care: The potential role of BTKi-based regimens in front-line treatment

06 Sep 2023
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Professor Simon Rule

Professor of Clinical Hematology,
Plymouth University Medical School,
United Kingdom
Global Clinical Head Acalabrutinib,
Haematology R&D,
AstraZeneca

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Dr. Liu, Sung-Yu Herman

Specialist in Hematology and Hematological Oncology

New paradigms in hepatitis management to address treatment challenges and barriers to care

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Professor Kim, Seung-Up

Department of Internal Medicine,
Yonsei University College of Medicine,
Yonsei Liver Center, Severance Hospital,
Seoul, Republic of Korea

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Dr. Wong, Yu-Jun Eugene

Consultant,
Department of Gastroenterology & Hepatology,
Changi General Hospital
Clinical Assistant Professor,
Duke-NUS Medical School,
Singapore

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