Omnihealth Practice

Methotrexate is more hepatotoxic to patients with psoriatic disorders than those with rheumatoid arthritis

Methotrexate is a multi-acting systemic antipsoriatic drug which simultaneously inhibits purine and pyrimidine synthesis, nitric oxide production and the transcription factor nuclear-factor kappa B (NFĸB) which is an inducible transcription factor for the production of pro-inflammatory cytokines and

RHEUMATOLOGY

09 Apr 2021

Combining xanomeline with trospium as antipsychotics for schizophrenia: Reduced side effects, better drug compliance

Adherence to antipsychotics is poor due to the presence of adverse effects.¹ Xanomeline is a muscarinic receptor agonist which lacks dopaminergic activity but causes considerable cholinergic reactions.¹ In a double-blind, phase 2 randomized clinical trial, xanomeline was combined with a peripherally

PSYCHIATRY

09 Apr 2021

A low transitional-1 B cell IL-10/Tnfα ratio predicts rejection and supports preemptive intervention for patients after kidney transplantation

Renal transplantation is the optimal treatment for end-stage renal disease as it allows rehabilitation with better survival than hemodialysis or peritoneal dialysis.¹ In 2016, the annual mortality rate per 100 patient-years in Hong Kong was only 1.88 for renal transplant recipients, compared to 17.8

NEPHROLOGY

09 Apr 2021

Mental incapacity: Prepare and protect while still capable, don’t wait till it is regrettableMental incapacity: Prepare and protect while still capable, don’t wait till it is regrettable

In routine clinical practice, a treatment decision can only legally proceed after patients are adequately informed and have voluntarily granted their consent for said decision.^1,2 However, in patients whose mental capacity are compromised, a decision made on their behalf from an unauthorized third p

PSYCHIATRY

28 Feb 2021

Dr. Leung, Lam-Ming Jess

Honorary Clinical Associate Professor,
Department of Psychiatry,
Faculty of Medicine,
The Chinese University of Hong Kong

Bruton’s tyrosine kinase inhibitors delay disease progression and extend survival in patients with relapsed/refractory mantle cell lymphoma

Mantle cell lymphoma (MCL) is a B cell malignancy that is typically clinically aggressive with a poor prognosis.¹ When MCL patients progress into relapsed/refractory MCL (RRMCL), the median overall survival (OS) is usually reduced to around 1 year. Currently, three Bruton’s tyrosine kinase inhibitor

HEMATOLOGY ONCOLOGY

30 Dec 2020

Prof. Tse, Wai-Choi Eric

Clinical Professor,
Department of Medicine,
Li Ka Shing Faculty of Medicine,
The University of Hong Kong

ENDO 2021

March 20-23, 2021 |

Virtual

Pharmacological management of non-alcoholic fatty liver disease in patients with T2DM

Among patients with type 2 diabetes mellitus (T2DM), the worldwide prevalence of non-alcoholic fatty liver disease (NAFLD) and advanced liver fibrosis are estimated to be 55% and 17%, respectively.1,2 When considering the NAFLD treatment, Dr. Diana Barb, Clinical Assistant Professor of the Division

DIABETES & ENDOCRINOLOGY

11 May 2021

Minimizing acute endocrinopathy associated with immune checkpoint inhibitors

Immunotherapy has revolutionized the treatment of cancer, yet its increasing use has exposed cancer patients to an increased risk of immune-related adverse events (irAEs).1,2 These adverse reactions are usually mild to moderate albeit severe irAEs which are occasionally reported in the literature ar

DIABETES & ENDOCRINOLOGY

11 May 2021

NCCN 2021

March 18-20, 2021 |
Virtual

More radiotracers approved for PSMA PET/CT scan in the metastatic castration-resistant prostate cancer diagnosis

Radiologic imaging has been a cornerstone in guiding treatment approaches for metastatic castration-resistant prostate cancer (mCRPC). However, conventional bone scintigraphy using 99Tc-MDP is limited by its low sensitivity towards prostate cancer cells and many mCRPC cases may remain undetected by

ONCOLOGY

11 May 2021

New perspectives on the management of unfit patients with acute myeloid leukemiaNew perspectives on the management of unfit patients with acute myeloid leukemia

Acute myeloid leukemia (AML) is an aggressive disease that predominantly affects older individuals.1 While hematopoietic stem-cell transplantation (HSCT) after induction chemotherapy is potentially curative, this option is not feasible for many older AML patients due to advanced age, coexisting cond

ONCOLOGY HEMATOLOGY

11 May 2021

AGA clinical practice guideline update: Palliative care management in patients with cirrhosis

Palliative Care (PC) is an approach to care that focuses on improving the quality-of-life of patients and their caregivers who are facing life-limiting illnesses.1 In order to meet the needs of the increasingly prevalent cirrhosis population, it is important that all clinicians are able to work toge

GASTROENTEROLOGY & HEPATOLOGY

08 Apr 2021

Semaglutide aids weight loss in adults with type 2 diabetes and reduces major adverse cardiovascular events

Weight control remains an indispensable component for the clinical management of type 2 diabetes mellitus (T2DM) in preventing cardiometabolic morbidity.1-3 People with T2DM who received weekly subcutaneous injection of semaglutide 2.4mg achieved superior and clinically meaningful reduction of body

DIABETES & ENDOCRINOLOGY

08 Apr 2021

Anti-IL-21 and liraglutide combination could preserve β-cell function in type 1 diabetes, a recent phase 2 study suggests

Being an autoimmune disease, type 1 diabetes (T1D) is characterized by the infiltration of immune cells into the pancreas that causes the destruction of insulin-producing β-cells in the pancreatic islets of Langerhans.1 While it has been the mainstay therapy for patients with T1D since its discovery

DIABETES & ENDOCRINOLOGY

08 Apr 2021

Novel oral agent effective in teens with moderate-to-severe atopic dermatitis

Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin condition with immune dysfunction that affects lesional and nonlesional skin.1 Characterized by pruritus, skin pain, eczematous lesions and dry skin, AD is associated with substantial comorbidity and impairment in a patient’s quality-o

DERMATOLOGY

08 Apr 2021

The American College Of Gastroenterology publishes their first-ever IBS clinical practice guidelines

Irritable bowel syndrome (IBS) is a highly prevalent, chronic disorder that significantly reduces patients' quality of life.¹ The management of IBS has been previously examined in several recent monographs, reviews and position statements that provide management recommendations based on the meta-ana

GASTROENTEROLOGY & HEPATOLOGY

28 Feb 2021

Expanding first-line renal cell carcinoma treatment to patients with favorable risks: A sharing of local cases

Renal cell carcinoma (RCC) is the most prevalent type of kidney malignancy, accounting for 90% of all cases.1 Characterized by susceptibility to both immunotherapeutic and anti-angiogenic approaches, RCC can be treated with a combination of tyrosine kinase inhibitors (TKIs) and immune checkpoint inh

ONCOLOGY NEPHROLOGY

01 Jun 2021

Dr. So, Tsz-Him

Clinical Assistant Professor,
Department of Clinical Oncology,
Li Ka Shing Faculty of Medicine,
The University of Hong Kong

First-line treatment with immunotherapy in metastatic squamous NSCLC

Immunotherapy has dramatically changed the therapeutic scenario in the treatment-naïve advanced NSCLC. While the single agent pembrolizumab has become the standard first-line therapy in patients with ≥50% PD-L1 expression on tumor cells,

ONCOLOGY

31 Aug 2020

Prof. Luis Paz-Ares

Head of Medical Oncology Department,
Hospital Universitario 12 de Octubre,
Madrid, Spain