Dapagliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor that was initially approved in 2014 for the treatment of type 2 diabetes mellitus (T2DM) and subsequently for heart failure with reduced ejection fraction (HFrEF), has recently received yet another approved indication by the United St

Children with Down syndrome are at an elevated risk of multiple malignancies and hematological disorders such as different types of leukemia.1,2 To better reflect the current risk association between Down syndrome and childhood leukemia, investigators from the United States had conducted a large, co

Chronic kidney disease (CKD), defined as the persistent reduction in kidney function, is a growing health concern in the elderlies with an estimated global mean prevalence of 34.3% for populations over the age of 70-years-old.1 Associated with multiple comorbidities, reduced kidney function is a str

Asthma is a chronic inflammatory disease of the airways that affects approximately 300 million people globally with about 5-10% of asthmatics being severe asthma.¹ Severe asthma typically requires treatment with high-dose inhaled corticosteroid (ICS) plus a second controller and/or systemic corticos

Accounted for 3.8% of all new cancer cases, gastric cancer (GC) was the sixth commonest cancer in Hong Kong in 2018.¹ While chemotherapy remains as the standard of care for advance GC or gastroesophageal junction cancer (GEJC), most chemotherapy regimens fail to provide substantial survival benefits