Omnihealth Practice

Interim analysis of a long-term safety and efficacy extension study of atogepant in episodic and chronic migraine prevention

Atogepant is an oral anti-migraine drug that blocks the calcitonin gene-related peptide (CGRP) receptor.¹ It was previously evaluated in the phase 3, randomized, double-blind, placebo-controlled trials ELEVATE and PROGRESS for the prevention of episodic migraine (EM) or chronic migraine (CM), respectively.¹

NEUROLOGY

05 Jul 2024

Final results from CHAMPION MG OLE demonstrated the long-term efficacy and safety of ravulizumab in adults with AChRAb+ gMG

Autoantibodies against the acetylcholine receptor (AChR) are often found in patients with generalized myasthenia gravis (gMG), which destroy the post-synaptic membrane of the neuromuscular junction (NMJ) via aberrant complement cascade activation.¹ Humanized monoclonal antibodies with a high affinity to the human terminal complement component C5 such as ravulizumab inhibit the membrane attack complex formation.¹ Previously, the 26-week randomized controlled period (RCP) of the phase 3 CHAMPION MG study demonstrated the efficacy and safety profile of ravulizumab in adult patients with anti-acetylcholine receptor antibody-positive (AChRAb+) gMG.¹

NEUROLOGY

05 Jul 2024

“Inclisiran first” strategy lowers LDL-C in real-world ASCVD patients: Results from the VICTORION-INITIATE trial

A reduction in LDL-C is associated with improvements in CV outcomes in patients with ASCVD.¹ As such, multiple guidelines recommend LDL-C targets of <55mg/dL and <70mg/dL based on baseline risks.¹ However, many patients fail their LDL-C goals due to clinical inertia, medication nonadherence, side effects, and/or poor healthcare access.¹ Inclisiran is a first-in-class siRNA that inhibits hepatic PCSK9 production and increases LDL receptor expression and LDL-C clearance.¹ In clinical studies, twice-yearly administration of inclisiran has been shown to achieve a 50% reduction in LDL-C.¹

CARDIOLOGY

08 Jul 2024

Emphasizing HAE diagnosis and management in the Asia-Pacific region with SHARP guidance

Hereditary angioedema (HAE) is a rare, yet potentially life-threatening, inheritable disease characterized by episodic attacks of cutaneous and submucosal swelling.1,2 Unfortunately, the adoption and implementation of international guidelines established in Asia-Pacific (AP) populations remains limi

08 May 2024

Dr. Li, Hei Philip

Clinical Assistant Professor,
Division Chief of Rheumatology & Clinical Immunology,
Department of Medicine,
The University of Hong Kong

Balancing sensitivity with specificity in cervical cancer screening by co-testing with HPV and cytology

The Hong Kong College of Obstetricians and Gynaecologists (HKCOG) has recently updated its guidelines on the prevention and screening of cervical cancer.¹ The latest recommendations incorporated recent evidence on the role of co-testing with human papillomavirus (HPV)-based screening and cytology-based screening.¹ In an interview with Omnihealth Practice, Dr. Wong, Ching-Yin Grace shared the rationale behind co-testing as the preferred testing modality in The Family Planning Association of Hong Kong as it offers concurrent triaging. The combination of sensitivity with HPV tests and the specificity with cytology tests allows for a more lenient screening schedule for women in Hong Kong without compromising the benefit of cervical cancer detection.

OBSTETRICS & GYNECOLOGY ONCOLOGY

09 May 2024

Dr. Wong, Ching-Yin Grace

Specialist in Obstetrics and Gynaecology

ACC 2024

April 6-8, 2024 | Atlanta, United States

Preventive PCI + OMT for vulnerable plaques reduces risk of cardiac events: The PREVENT trial

Patients with intracoronary imaging-defined vulnerable plaques (VP) have a higher risk of experiencing major adverse cardiac events.1 While optimal medical therapy (OMT) is the standard approach to stabilize plaque vulnerability, the effectiveness and safety of focal preventive percutaneous coronary

CARDIOLOGY

07 Jun 2024

Mandibular advancement device shows similar effectiveness as CPAP in reducing BP in OSA patients

Obstructive sleep apnea (OSA) is a modifiable cause of hypertension but is often underdiagnosed.1 Patients with hypertension are at a higher risk for cardiac and cerebrovascular diseases and are thus recommended to undergo screening and treatment of OSA.1 While the continuous positive airway pressur

CARDIOLOGY

07 Jun 2024

AAN 2024

April 13-18, 2024 | Denver, United States

Novel MRI-based H-SeLECT risk score enhances the prediction of post-stroke epilepsy

Stroke is one of the most common causes of adult-onset seizures, which may occur early (≤7 days) or late (>7 days) after stroke.1 Post-stroke epilepsy (PSE) is defined as any unprovoked seizure after the acute phase (>7 days) of stroke.1 Approximately 4% of stroke patients experience PSE in the firs

NEUROLOGY

18 Jun 2024

Shotgun metagenomic analysis reveals gut dysbiosis in epilepsy patients

Despite the increasing availability of anti-seizure medication options, a substantial proportion of epilepsy patients, estimated at 30%-40%, continue to have drug-resistant disease.1 As such, treatment approaches beyond just pharmacotherapy have garnered increasing interest in recent years.1 Dietary

NEUROLOGY

14 Jun 2024

SC administration of vedolizumab receives FDA approval for Crohn’s disease maintenance

CD is an inflammatory bowel disease (IBD) with rising incidence and prevalence worldwide, characterized by abdominal pain, diarrhea, fatigue and weight loss. While corticosteroids (CS), immunomodulators and biologics are commonly used, achieving sustained remission remains varia

GASTROENTEROLOGY & HEPATOLOGY

08 Jul 2024

Local EHR-based ML model accurately predicts risk of severe hypoglycemia in older adults with diabetes

Severe hypoglycemia (SH), a dangerously low blood glucose level (<70mg/dL) that requires assistance from a third party, is a major concern for older adults with diabetes. Beyond the immediate medical emergency, SH is associated with a range of serious consequences, including prolonged hospitalizations, higher healthcare expenditures, increased risks of cardiovascular disease, falls, cognitive decline and elevated mortality. In response to this clinical challenge, researchers from CU Medicine developed a novel machine learning (ML) model capable of predicting the one-year risk of SH requiring hospitalization in older adults with diabetes. This predictive tool has the potential to enable targeted interventions and improve diabetes management outcomes in this high-risk population.

DIABETES & ENDOCRINOLOGY

02 Jul 2024

Global consensus reached on the definition and diagnostic criteria for GPP

GPP is a rare and severe auto-inflammatory disease characterized by recurrent, sudden, flares of widespread painful erythema and eruption of sterile pustules.^1,2 GPP flares may lead to life-threatening multi-organ complications if left untreated hence rapid and accurate diagnosis is needed.^2,3 However, clinical presentation of GPP is heterogeneous and symptoms may resemble other skin conditions, making accurate and timely diagnosis and treatment challenging.^1,3 As there is a lack of standardized international guidelines for GPP diagnosis, the International Psoriasis Council (IPC) established a Pustular Psoriasis Working Group to address these challenges and develop an international consensus definition and diagnostic criteria for GPP.^1,3

DERMATOLOGY

08 Jul 2024

Sequencing retreatment with anti-CD38 mAb in heavily pretreated RRMM patients

Patients with multiple myeloma (MM) are highly susceptible to developing relapsed and refractory (RR) disease towards lenalidomide and proteasome inhibitors (PIs) and require new active treatments at relapse. As such, novel treatment options like isatuximab, a monoclonal antibody (mAb) that targets

HEMATOLOGY

06 Mar 2024

Professor Yong, Kwee

University College London,
United Kingdom

Examining real-world effectiveness of fremanezumab in migraine prevention: Insights from the 3^rd interim analysis of PEARL

Migraine is a neurologic disorder characterized by recurrent attacks of pulsating headache that may be accompanied by an array of sensory symptoms or even cognitive dysfunction. Traditional treatments for migraine prevention are rarely disease-specific with unsatisfactory effectiveness and tolera

NEUROLOGY

01 Jan 2024

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Overseeing local ocular health with a watchful gaze: Consensus on managing center-involving DME in Hong Kong

Diabetic macular edema is a prevalent cause of vision loss among individuals in the working-age population, characterized by the disruption of the blood-retinal barrier and the accumulation of fluid and serum macromolecules in the intercellular space. As the incidence of diabetes mellitus

OPHTHALMOLOGY

02 Jul 2024

Refining the management of hyperkalemia in the Asia-Pacific region: Consensus statements from a multidisciplinary expert panel

Hyperkalemia, defined as serum potassium >5.0mmol/L, is a potentially lethal condition as it hinders muscle function and myocardial excitability, which may contribute to arrhythmias and sudden cardiac deaths. Epidemiological data suggests the global prevalence of hyperkalemia is around 6.3%, but the

NEPHROLOGY

20 Jun 2024

Nephrology. 2024

Yap YHD, Ma CWR, Wong CKE, Tsui SHM, Yu YTE, Yu V, Szeto CC, Pang WF, Tse HF, Siu CDW, Tan CBK, Chen WCW, Li CL, Chen W, Chan TM. Consensus statement on the management of hyperkalaemia—An Asia-Pacific perspective. Nephrology. 2024;29(6):311-324.

Case sharing: Improving treatment outcome in MDD patients with timely brexpiprazole augmentation

Treatment-resistant depression (TRD) is defined as treatment failure following ≥2 trials of antidepressant therapy (ADT) at adequate doses, duration and adherence.1 Around 30% of patients with major depressive disorder (MDD) become resistant to conventional treatments.2 TRD is independently associa

PSYCHIATRY

09 May 2024

Dr. Lai, Chi-Lun

Specialist in Psychiatry

Case sharing: Brexpiprazole augmentation in MDD patients with anxiety symptoms provides the trifactor of clinical outcomes, patient compliance and functional recovery

Among patients suffering from major depressive disorder (MDD), more than half of them are encumbered with comorbid anxiety symptoms.1 They represent a more severe form of depression and are often associated with higher morbidity.2 Recovery is more difficult due to a reduced likelihood of response to

PSYCHIATRY

13 Mar 2024

Dr. Tso, Kwok-Chu

Specialist in Psychiatry

Reshaping CLL care: Acalabrutinib-based regimens at the forefront of CLL management

HEMATOLOGY

09 May 2024

Dr. Jeff Sharman

Willamette Valley Cancer Institute and Research Center,
Eugene, United States

Beyond transfusion - The emerging role of luspatercept in transfusion-dependent β-thalassemia

HEMATOLOGY

05 Mar 2024

Professor Vip Viprakasit

Professor of Pediatrics,
Director of Thalassemia Research Program,
Division of Hematology & Oncology,
Department of Pediatrics & Siriraj Thalassemia Center,
Faculty of Medicine Siriraj Hospital,
Mahidol University, Bangkok, Thailand

Infographics

OPHTHALMOLOGY NEPHROLOGY

Insight into CKD progression: Ophthalmalogical outcomes and eGFR in non-diabetic CKD

21 Jun 2024

CARDIOLOGY

CKD or No CKD: Knocking down CV risks with rosuvastatin

08 Jul 2024

NEUROLOGY

Longitudinal assessment of MCI and dementia in an essential tremor cohort

08 Jul 2024

HEMATOLOGY

From bridging to maintenance: A case of gilteritinib in RR FLT3 AML patients undergoing HSCT

09 May 2024

NEUROLOGY

Real-world effectiveness of fremanezumab in migraine prevention

08 Apr 2024

HEMATOLOGY CARDIOLOGY

Incidence of anemia with long-term low-dose aspirin

18 Mar 2024

Decoding the spectrum of tolerance in fish allergies

04 Jan 2024

DIABETES & ENDOCRINOLOGY CARDIOLOGY

Earlier and higher risk of CVD with a younger T2D diagnosis

04 Jan 2024

DIABETES & ENDOCRINOLOGY

U-shaped relationship between sleep duration and T2DM regardless of traditional lifestyle risk factors

17 Nov 2023

RESPIROLOGY

Brain Gliosis: A Potential Origin of Persistent Post-COVID-19 Depressive and Cognitive Symptoms

17 Nov 2023

DIABETES & ENDOCRINOLOGY NEUROLOGY

The nuanced link between prediabetes and dementia

23 Aug 2023

NEUROLOGY RHEUMATOLOGY

Connecting the dots between Parkinson’s disease and rheumatoid arthritis

12 Jul 2023

CARDIOLOGY PEDIATRICS

Cardio-oncology monitoring in pediatric populations - Delphi consensus recommendations from an Australian and New Zealand expert group

28 Apr 2023

RESPIROLOGY

Targeting TSLP for severe asthma - Tezepelumab updates from the 2023 American Academy of Allergy Asthma & Immunology Annual Meeting

06 Apr 2023

HEMATOLOGY PEDIATRICS

A new way out for alpha thalassemia major - Give them a chance at life with In-utero transfusions

15 Mar 2023

RESPIROLOGY

Beware of overlapping phenotypes in severe asthma: The eosinophilia and IgE double whammy

27 Feb 2023

NEPHROLOGY

Stay on the path of treatment - Take on a high-K with ease
ASN abstract highlight on sodium zirconium cyclosilicate and hyperkalemia

23 Feb 2023

RESPIROLOGY

Real-world effectiveness of benralizumab around the globe

06 Dec 2022

RESPIROLOGY

Remission is within reach - Target the underlying drivers of inflammation with benralizumab

19 Sep 2022

ONCOLOGY RESPIROLOGY

PACIFIC-6: Durvalumab after CRT showed similar safety profile as the PACIFIC regimen with encouraging efficacy data in frailer and older patients with stage 3, unresectable NSCLC