The phase 2 FLAURA2 study found that first-line combination of osimertinib and chemotherapy (CT) offered significant survival benefits among patients who were diagnosed with epidermal growth factor receptor-mutated (EGFRm) advanced non-small cell lung cancer (NSCLC) compared to first-l

Results from the phase 3 CheckMate 816 study had found that neoadjuvant nivolumab plus chemotherapy (CTx) induced clinically significant and sustained benefits in the event-free survival (EFS) and overall survival (OS) of patients with resectable non-small cell lung cancer (NSCLC) comp

While platinum-based chemotherapy (CTx) has been the standard first-line (1L) treatment for locally advanced metastatic urothelial carcinoma (la/mUC) for decades, many patients continue to experience disease progression after treatment, resulting in poor prognosis and low 5-year surviv

Immune checkpoint inhibitor (ICI)-based treatments are one of the front-line options for patients with advanced non-small cell lung cancer (NSCLC).¹ However, no optimal duration has been defined.¹ At the ASCO 2023 Annual Meeting, Dr. Lova Sun from the University of Pennsylvania, the United States (US), presented the results of a US study that investigated the clinical practice patterns surrounding ICI treatment discontinuation at 2 years.¹ Furthermore, the association between the duration of therapy with overall survival (OS) was evaluated by comparing patients who received ICIs for 2 years with those who had received ICIs beyond 2 years.¹

Non-small cell lung cancer (NSCLC) accounts for 85%of all types of lung cancer and is the most common cancer in Hong Kong with a total of 5,575 cases in 2019.^1,2 Approximately 30% of NSCLC patients are diagnosed as early stage, and surgical resection is the preferred treatment option for possibly co

A retrospective study on a pediatric population has shown that neurologic manifestations (NMs) in patients with acute leukemia (AL), relating to a greater mortality rate.1 AL is the most prevalent childhood cancer, which accounts for one-third of all cancers within the age range.1 Although the survi

In the 64th American Society of Hematology (ASH) Annual Meeting and Exposition 2022, Dr. Johannes Schetelig, on behalf of the Study Alliance Leukemia and the German Cooperative Transplant Study Group, presented his group’s study to prove their hypothesis that salvage chemotherapy before allogeneic h

Among different subtypes of breast cancer, triple-negative breast cancer (TNBC) is associated with the least overall survival (OS).¹ The use of immune checkpoint inhibitors, such as programmed death 1 (PD1) or programmed death-ligand 1 (PD-L1), benefits TNBC patients.¹ An interim analysis of a phase 3 trial revealed that administration of pembrolizumab, an immune checkpoint inhibitor, along with neoadjuvant chemotherapy, resulted in a pathological complete response in a significant number of patients with high-risk early TNBC.¹

Despite recent advances in oncology, drug resistance and disease relapse have remained a significant unmet need among non-small cell lung cancer (NSCLC). Recently, the development of novel therapeutics including tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs) have made multiple breakthroughs in the treatment of NSCLC. In a virtual meeting and clinical debate, “Durvalumab in EGFRm Stage III NSCLC – To Offer or Not to Offer?”, Dr. Victor Lee summarized the key studies of NSCLC treatments, including the phase 3 PACIFIC trial of an anti-programmed cell death receptor ligand 1 (PD-L1) drug, durvalumab. Dr. Oscar Chan and Dr. Jonathan Nyaw then discussed the applications and other considerations of the durvalumab regimen among stage 3 Epidermal Growth Factor Receptor mutated (EGFRm) NSCLC patients in the clinical setting.