Methotrexate is a multi-acting systemic antipsoriatic drug which simultaneously inhibits purine and pyrimidine synthesis, nitric oxide production and the transcription factor nuclear-factor kappa B (NFĸB) which is an inducible transcription factor for the production of pro-inflammatory cytokines and

During the EULAR 2020 e-congress, Dr. Robert Landewé, MD, Ph.D., Professor of the Amsterdam Rheumatology Center at the University of Amsterdam, and chair of the Department of Rheumatology at the Zuyderland Medical Center Heerlen, the Netherland, shared his perspective on the provisional EULAR