Osteoporosis per se is not a serious medical condition. Yet, it is the occurrence of fragility fractures in osteoporotic patients that makes osteoporosis a harmful disease. Among all types of osteoporotic fractures, vertebral fracture (VF)is by far the most prevalent, which could lead to immobility, loss of daily functioning and social isolation in osteoporotic patients.^1,2 Despite the catastrophic consequences, VF remains seriously underdiagnosed with three-quarters of patients not seeking medical attention.¹ Recognition of VF and appropriate treatment at early stage is crucial to reducing future fracture risk, as well as preventing patients’ pain, deformity, and suffering.¹ In a recent interview with Omnihealth Practice, Dr. Wong, Sze-Hung discussed the looming threat of VF in Hong Kong and shared a clinical case to demonstrate the effectiveness of romosozumab, a novel anti-osteoporotic treatment option with a dual effect, in postmenopausal women with severe osteoporosis.